Patients diagnosed with ALS receive a multidisciplinary evaluation every 3 months. In addition, we provide medical, social and home support. To share our expertise regarding care for ALS patients, we provide training sessions for medical and paramedical staff, and organise a symposium with other French ALS Centers. Our research interests include epidemiology, cognition and nutrition. To this extent, we establish internal and multicenter research protocols and collaborate with the pharmaceutical industry in therapeutic research.