The Montpellier ALS center is included in the Department of Neurology of the University Hospital Gui de Chauliac, and is headed by Prof. Dr. William Camu. Established in 1988, the center obtained the national label of ALS center by the Ministry of Health in 2003. On a regular basis, between 500 and 600 patients with motor neuron diseases are in care. Research aspects of the center include epidemiology, phenotype, genetics, biomarkers and clinical trials. The center has participated in all the major trials in ALS since 1989, and conducted a series of pilot trials in ALS. Through national and international collaborations, more than 200 papers have been published by the center in referenced journals.