Our centre is based in the largest public hospital in Italy (the “Città della Salute e della Scienza” hospital of Torino). We follow about 350 patients each year, both locally and nationwide. We have a diagnostic laboratory and a molecular genetics laboratory. Our scientific studies include both clinical and basic research of ALS. In the last decade, we have participated in 5 large international randomized clinical trials on innovative drugs in ALS. We have a multidisciplinary group and a daily ALS clinic. We also provide psychological, neuropsychological and neurophysiological services.