Patients

Creating a world without ALS, together

TRICALS is a unique collaboration uniting patients, top researchers and ALS foundations. We have put together a radical new way to find effective treatments – and ultimately, a cure – for ALS. Together, we can make ALS treatable.

Join our highway towards a cure

Currently, less than 5% of patients participate in clinical trials. TRICALS aims to open clinical trials to all people with ALS – giving them and their loved ones the chance to make a meaningful contribution to ridding the world of ALS, forever.

The direct involvement of people with ALS is essential and urgent. Each person with ALS holds an important piece of the puzzle, and putting the puzzle together will help us to find new and more effective treatments. We believe that with our new approach, where we all work together, we can make the difference. We can turn ALS into a condition that is treatable. When we all work together, we can build a highway towards a cure.

How does TRICALS work?

TRICALS aims to speed up the development of new medicines for ALS. To effectively do that, the direct involvement of people with ALS is essential and urgent. Each person with ALS holds an important piece of the puzzle, and putting the puzzle together will help us to find new and more effective treatments.

You can help by registering with TRICALS. After your permission, we will inform you on trials that are recruiting patients and you will be invited to an ALS centre that you choose, for further counselling and screening. Even if there are no suitable trials, your participation will help us to further unravel this complex disease by submitting your data, and participating in other types of scientific research.

Register now
Step 1

Register as a patient

If you are living with ALS (also known as MND) you can register for TRICALS. During your registration you will be asked for your personal details and to submit some basic information about how ALS affects you.

Step 2

Pre-screening questionnaire

When you have successfully registered, we will send you an online pre-screening questionnaire. Trained staff from your country’s TRICALS centre will then evaluate your responses

Step 3

Screening & participating

When you fulfill the minimum requirements of an active or new trial, you will be invited for screening in one of the participating trial centres in your country. If you fulfil all the requirements, you can participate in the trial.

Our mission is simple: find an effective treatment for patients with ALS

Josefina - patient

Strength in unity

“I would say that there is strength in unity. Although there are only few of us, if we all contribute a grain of sand, in the end we can build a beach”

Mia - patient

Making a difference

“I find it important as a patient to have an influence and to convince other patients that they will join and make a difference”

Current trials
Recruiting
Phase iii

ALXN1210-ALS-308 trial

Industry trial
This phase 3 trial aims to study the safety and efficacy of the drug ‘ravulizumab’ in people living with ALS. To register for this study, you should contact your local ALS centre or treating physician.
Read more
Recruiting
Phase iii

VALOR study

Industry trial
Biogen is conducting a clinical trial to evaluate the safety and potential efficacy of an investigational drug for people with Amyotrophic Lateral Sclerosis (ALS) with a SOD1 gene mutation.
Read more
In preparation
Phase iii

The Lighthouse 2 trial

Investigator initiated trial
The Lighthouse 2 study is a phase 3 clinical trial in which we will investigate the efficacy of the drug Triumeq.
Read more
In preparation
Phase iii

MAGNET

Platform trial
MAGNET is an innovative clinical platform trial in which multiple treatments for ALS are investigated simultaneously.
Read more
Recruiting
Phase iii

TUDCA-ALS

Investigator initiated trial
This trial will evaluate the efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment for people with ALS.
Read more
Register as a patient

TRICALS aims to speed up the development of new medicines for ALS. You can help by registering with TRICALS. The participation of patients in clinical trials is necessary to find better treatments.