Lille ALS Center

CHU Lille

The multidisciplinary specialists’ team of the Lille ALS Center aims to minimize ALS morbidity and optimize quality of life. Using a translational approach, we develop new therapeutic concepts for neurodegenerative diseases and especially for ALS.

 

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CHU Lille

Our ALS Center provides multidisciplinary care to minimize symptoms and optimize quality of life. To achieve this, multiple specialists coordinate patient care by monitoring disease progression, anticipating complications, providing technological tools, adapting the living environment and providing social support to help people stay at home. We have a lot of expertise in early planning of patient care and coordination of care for patients at home (including via teleconsultation). We also provide information about treatments and conduct ethical assessments with partners from the health sector, the medical social sector, the hospital sector and home care.

We take a translational approach in our research, with activities ranging from cell and mouse models to the assessment of large multicenter cohorts of patients (PULSE study; ClinicalTrials.gov: NCT02360891). We are currently developing two new treatment strategies: 1) Conservative iron chelation (FAIR ALS-II trial; ClinicalTrials.gov: NCT0329293069) and 2) a novel biotherapy based on the physiological healing system in the platelets (GIFT project). The PULSE project, a collaboration of 17 French ALS centers and supported by the Patient Association (ARSLA), is led by Professor David Devos. He is also the principal investigator of the FAIR ALS-II trial.

Contact
Location
Centre SLA, Neurologie, Hopital Salengro, CHU, 59037, lille cedex

Specialists

Veronique Danel-Brunaud

Consultant Neurologist and Head of ALS Center

Dr Veronique Danel-Brunaud is head of the Lille ALS Center. She is […]

Veronique Danel-Brunaud
Current trials
Recruiting
Phase iii

ATLAS trial

Industry trial
Biogen is conducting a clinical trial to evaluate the efficacy and safety and of an investigational drug for adults who do not have any clinical signs or symptoms of Amyotrophic Lateral Sclerosis (ALS) (that definitely indicate the onset of ALS) but do carry a certain superoxide dismutase 1 (SOD1) gene variant.
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Recruiting
Phase iii

FUSION trial

Industry trial
In this study we investigate the safety and efficacy of the study drug ‘ION363’ for the treatment of ALS caused by mutations in the FUS gene. About 1% to 5% of ALS cases are caused by FUS mutations.
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Active
Phase iii

PHOENIX trial

Industry trial
Amylyx Pharmaceuticals Inc is conducting a phase 3 trial to determine the safety and efficacy of their compound 'AMX0035' for the treatment of ALS.
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Active
Phase iii

ADORE trial

Industry trial
Ferrer is conducting a phase 3 trial to evaluate the safety and potential efficacy of an investigational drug for people with Amyotrophic Lateral Sclerosis (ALS).
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Recruiting
Phase iii

COURAGE-ALS Trial

Industry trial
In the COURAGE-ALS study, we are investigating the efficacy and safety of the drug ‘reldesemtiv’ for the treatment of ALS. This clinical trial is sponsored by Cytokinetics.
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Active
Phase ii

APL2-ALS-206 Trial

Industry trial
In this phase 2 study, we are investigating the safety and efficacy of the drug pegcetacoplan for the treatment of ALS. This trial is sponsored by Apellis Pharmaceuticals.
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Active
Phase iii

TUDCA-ALS

Investigator initiated trial
This trial will evaluate the efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment for people with ALS.
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