We cover a population of 455.000 inhabitants and follow approximately 30 ALS patients at any given time. We develop advanced in vitro modeling of patient-derived neural network function. We plan to do population-based research on patient samples obtained from the Nord-Trøndelag Health Study (www.ntnu.edu/hunt). Finally, we are establishing a National ALS registry. The neurodegenerative research initiative of which ALS research is a part is organized within the TrønderBrain research group.