The ALS Centre, belonging to the First Division of Neurology, University Hospital “Università degli Studi della Campania Luigi Vanvitelli” in Naples (Italy) is one of the most endorsed ALS centers in Southern Italy, involved in several major national and international clinical trials on ALS (such as, recently: TUDCA-ALS; RNS60-ALS; Co-ALS). We see approximately 80 new patients every year, and care for about 250 patients in a year. Our research activity is performed at the MRI Research Centre of the University of Campania Luigi Vanvitelli. This centre of excellence is based on a collaborative and multi-investigator neuroimaging research environment (including neurologists, neuropsychologists, bioinformaticians, and bioengineers) and focused on medical applications of advanced functional and structural magnetic resonance imaging techniques to study the brain. Moreover, our ALS centre is involved in 3 main clinical/research networks: European Reference Network for rare disease (ERN) – Neuromuscular Diseases (Euro-NMD); ITALSGEN (ITalian Consortium for ALS GENetics); and NiSALS (Neuroimaging Society in ALS) Consortia.