ALS Center, IRCCS Istituto Auxologico Italiano

University of Milan Medical School

The ALS Centre is a referral institution in Italy for the diagnosis and care of patients affected by ALS and other motor neuron diseases, offering a multidisciplinary team, clinical trials, genetic diagnosis and biomarker investigations.

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University of Milan Medical School

We offer adequate clinical diagnosis with the support of a multidisciplinary team and a centre for clinical trials. Research in the Laboratory of Neuroscience mainly focuses on genetics of ALS, ALS disease mechanisms using in vitro cell models, iPSCs as a bioassay of clinical relevance, and biomarker identification. We have made a big effort to develop eye tracking and BCI technologies for the definition of neuropsychological changes in people with ALS. The Milan ALS Centre has been audited by FDA in 1997 for a clinical trial.

Contact
Location
International Medical School, University of Milan, Milan, Metropolitan City of Milan, Italy

Our Specialists

Vincenzo Silani

Professor of Neurology and Chairman

Vincenzo Silani is Professor of Neurology, Director of the Department of Neurology-Stroke […]

Vincenzo Silani
Current trials
Recruiting
Phase iii

ATLAS trial

Industry trial
Biogen is conducting a clinical trial to evaluate the efficacy and safety and of an investigational drug for adults who do not have any clinical signs or symptoms of Amyotrophic Lateral Sclerosis (ALS) (that definitely indicate the onset of ALS) but do carry a certain superoxide dismutase 1 (SOD1) gene variant.
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Recruiting
Phase iii

FUSION trial

Industry trial
In this study we investigate the safety and efficacy of the study drug ‘ION363’ for the treatment of ALS caused by mutations in the FUS gene. About 1% to 5% of ALS cases are caused by FUS mutations.
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Active
Phase iii

PHOENIX trial

Industry trial
Amylyx Pharmaceuticals Inc is conducting a phase 3 trial to determine the safety and efficacy of their compound 'AMX0035' for the treatment of ALS.
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Active
Phase iii

ADORE trial

Industry trial
Ferrer is conducting a phase 3 trial to evaluate the safety and potential efficacy of an investigational drug for people with Amyotrophic Lateral Sclerosis (ALS).
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Recruiting
Phase iii

COURAGE-ALS Trial

Industry trial
In the COURAGE-ALS study, we are investigating the efficacy and safety of the drug ‘reldesemtiv’ for the treatment of ALS. This clinical trial is sponsored by Cytokinetics.
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Active
Phase ii

APL2-ALS-206 Trial

Industry trial
In this phase 2 study, we are investigating the safety and efficacy of the drug pegcetacoplan for the treatment of ALS. This trial is sponsored by Apellis Pharmaceuticals.
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Active
Phase iii

TUDCA-ALS

Investigator initiated trial
This trial will evaluate the efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment for people with ALS.
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