The Oxford clinic’s core team comprises three neurology consultants, a nurse consultant, a specialist nurse and occupational therapist. We work closely with respiratory and gastroenterology colleagues. There are ~250 individuals living with MND and related disorders in active follow-up, with 130 new patient referrals annually. In addition to participating in clinical trials, we run a number of research programs. Professor Talbot leads on the cellular biology including the development of rodent models and stem cell-derived motor neuron culture systems. Professor Turner leads a large biomarker program combining multimodal neuroimaging with biofluid sampling. Dr Thompson is focused on biofluid protein characterization, including pre-symptomatic cohorts through our Families for the Treatment of Hereditary MND (FaTHoM) initiative. We organise MND training courses for allied healthcare professionals.