ALS trial research

The highway towards a cure

TRICALS is the largest European research initiative to find a cure for ALS to date. 48 top research centres in 16 countries have joined hands with patient organisations and fundraisers to reach our one goal: find effective treatments for ALS.

Find out more about the highway 
towards a cure in this video.
Creating a world without ALS, together

The very best experts from top research centres around the globe have teamed up with patient organisations, fundraisers and pharma companies in a unique international collaboration to find a cure for ALS

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The best research centers

Top research centres in 16 countries have joined hands with patients’ organisations and fundraisers to reach our one goal: find a treatment for ALS within 5 years

Make a difference

Join us in our mission to make ALS treatable. Support one of our running campaigns or start your own. Together we will create a world without ALS.

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Danny - patient

The perfect platform to unite

“I believe TRICALS will be the perfect platform to unite patients, pharma and researchers that want to contribute to get rid of this disease”

Current trials
Recruiting
Phase ii

AP101-02

Gesponsorde Trial

In this study we investigate the safety, tolerability, pharmacodynamics markers and pharmacokinetics (how a drug is absorbed and excreted) of AP-101 in patients with familial and sporadic amyotrophic lateral sclerosis (ALS). Currently, we are only looking for patients with familial ALS (caused by a SOD1 gene mutation) to participate in the study. This study is sponsored by AL-S Pharma.

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Recruiting
Phase ii

DAZALS trial

Industry trial

In this study, an investigational oral drug named dazucorilant (also called CORT113176) is being studied in people living with ALS (also known as MND) to understand its safety (side effects) and to determine if dazucorilant can slow down the worsening of the disease. The effects of dazucorilant will be compared to the effects of a placebo. This study is sponsored by Corcept Therapeutics.

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Recruiting
Phase iii

ATLAS trial

Industry trial

Biogen is conducting a clinical trial to evaluate the efficacy and safety and of an investigational drug for adults who do not have any clinical signs or symptoms of Amyotrophic Lateral Sclerosis (ALS) (that definitely indicate the onset of ALS) but do carry a certain superoxide dismutase 1 (SOD1) gene variant.

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Recruiting
Phase iii

FUSION trial

Industry trial

In this study we investigate the safety and efficacy of the study drug ‘ION363’ for the treatment of ALS caused by mutations in the FUS gene. About 1% to 5% of ALS cases are caused by FUS mutations.

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Active
Phase iii

TUDCA-ALS

Investigator initiated trial

This trial will evaluate the efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment for people with ALS.

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Completed
Phase iii

ADORE trial

Industry trial

Ferrer is conducting a phase 3 trial to evaluate the safety and potential efficacy of an investigational drug for people with Amyotrophic Lateral Sclerosis (ALS).

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Active
Phase iii

PHOENIX trial

Industry trial

Amylyx Pharmaceuticals Inc is conducting a phase 3 trial to determine the safety and efficacy of their compound ‘AMX0035’ for the treatment of ALS.

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Recruiting
Phase ii

CARDINALS

Industry trial

The CARDINALS clinical research study is evaluating a study drug (Utreloxastat) to see if it can help slow ALS symptoms. Researchers will also test the safety and tolerability of the study drug and how the body responds to it. The study drug is a liquid that is swallowed 2 times a day.

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Do you have any questions?

For general inquiries please contact us by using the contact form. For questions about clinical trials, please contact a TRICALS center close to you.