Patients

Creating a world without ALS, together

TRICALS is a European collaboration uniting patients, top researchers and ALS foundations. We’ve put together a radical new way to find effective treatments – and ultimately, a cure – for ALS. Together, we can make ALS treatable.

Join our highway towards a cure

Currently, less than 5% of patients participate in clinical trials. TRICALS aims to open clinical trials to all people with ALS – giving them and their loved ones the chance to make a meaningful contribution to ridding the world of ALS, forever.

The direct involvement of people with ALS is essential and urgent. Each person with ALS holds an important piece of the puzzle, and putting the puzzle together will help us to find new and more effective treatments. We believe that with our new approach, where we all work together, we can make the difference. When we all work together, we can build a highway towards a cure.

How does TRICALS work?

TRICALS aims to speed up the development of new medicines for ALS. To effectively do that, the direct involvement of people with ALS, PMA and PLS is essential and urgent. Each person with ALS, PMA and PLS holds an important piece of the puzzle, and putting the puzzle together will help us to find new and more effective treatments.

You can help by registering with TRICALS. After your permission, we will inform you on trials that are recruiting patients and you will be invited to an ALS centre that you chose, for further counselling and screening. Even if there are no suitable trials, your participation will help us to further unravelling this complex disease by submitting your data, and participating in other types of scientific research.

Register now
Step 1

Register as a patient

If you are an ALS, PMA or PLS, you can register as a patient in the TRICALS database. During registration you will be asked for your personal details and to submit some basic information about your disease.

Step 2

Pre-screening

When you have succesfully registered trained staff from your countries’ TRICALS centre will look at your data and will invite you for a pre-screening by phone.

Step 3

Screening

If your pre-screening is successful and you fulfill the minimum requirements of an active trial, you will be invited for a screening in one of the participating trial centers in your country. If this screening is successful you can participate in an active trial.

Our mission is simple: find effective treatments for ALS

Josefina - patient

Strength in unity

“I would say that there is strength in unity. Although there are only few of us, if we all contribute a grain of sand, in the end we can build a beach”

Mia - patient

Making a difference

“I find it important as a patient to have an influence and to convince other patients that they will join and make a difference”

Current trials
In preparation
Phase iii

PreLude (Lithium carbonate)

Platform trial arm

Within an innovative platform design study, we will evaluate the efficacy of lithium carbonate in UNC13a homozygous patients.

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In preparation
Phase ii

Lighthouse (Triumeq)

Platform trial arm

Within an innovative platform design study, we will evaluate the efficacy of Triumeq, a therapy developed for treatment of HIV that has shown to slow progression in ALS

Read more
In preparation
Phase iii

iAdore (Oral edaravone)

Platform trial arm

Within an innovative platform design study, we will evaluate the efficacy of oral edaravone (TW001), a formulation that reduces oxidative stress

Read more
Register as a patient

TRICALS aims to speed up the development of new medicines for ALS. You can help by registering with TRICALS. The participation of patients in clinical trials is necessary to find better treatments.